ASTRAZENECA PLC

CUSIP: 46353108 Class: Depository Receipt

SPHERA FUNDS MANAGEMENT LTD.'s Holding History (CIK: 0001496201)

Note: Option positions (PUT/CALL) are excluded.

Q4 2014
Shares 86,637 Value ($000) $6,098 Avg Close — Range —
Q3 2014
Shares 120,000 Value ($000) $8,573 Avg Close — Range —